Tissue-specific exposure of chromatin structure at the 5' terminus of the rat preproinsulin II gene.
نویسندگان
چکیده
The 5' terminus of the rat preproinsulin II gene exhibits a tissue-dependent DNase I sensitivity. Only in the chromatin froma pancreatic beta-cell tumor, but not in liver, spleen, kidney, or brain chromatin, is a region at and before the 5' end of the gene exposed to cleavage. The region of exposure extends 250-300 base pairs upstream from the 5' terminus of the preproinsulin mRNA. Such a region may allow control sequences special access to regulatory proteins.
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ورودعنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 78 3 شماره
صفحات -
تاریخ انتشار 1981